To Sir, With Love.

In this biography, the life of William Hugh Isbister is traced through three continents, where he planted the seeds of academic surgery into a generation of leaders in colorectal surgery. This ultimately improved the care for thousands of patients. His last station in Saudi Arabia made a huge impact on the country. I hope this article inspires others to write about their mentors who were important in their development as surgeons and physicians. Short biographies of these important figures will serve as a valuable historical record for generations to come.

American Proctology Before 1899, Part 2: The Rise of the Rectal Specialists.

Joseph M. Mathews' study at St. Mark's Hospital (London) in the 1877 to 1878 winter was followed shortly by a landmark move toward specialization in the United States: Mathews' heading of a Special Commission on Rectal Diseases appointed at the 23rd Annual Session of the Kentucky State Medical Society, held April 2 to 4, 1878. Various "rectal specialists," under various makeshift titles, were lecturing and publishing by the mid-1890s. The world's first proctologic journal, published between 1894 and 1898, was Mathews' Medical Quarterly, from its inception interpellating a community of colleagues.

American Proctology Before 1899, Part 1: "Shoals of Quacks"-The Itinerant Pile Doctor.

The early history of the American medical specialty of proctology before the 1899 establishment of the American Proctologic Society was animated by an extensive scene of itinerant pile doctors, from at least as far back as 1871. It was inspired by the initially proprietary carbolic acid injection treatment of hemorrhoids credited to Milton W. Mitchell (1833?-1887), long known only from oral history. Expanded entrepreneurial approaches seen in the 1880s are exemplified by the work of the initial exploiters of Mitchell's method, Alexander William Brinkerhoff (1821-1887) and son, and a mid-1920s recommercialization of "ambulant proctology" by its ambassador Charles Elton Blanchard.

British Surgeon Frederick Salmon (1796-1868) and His "Trans-Fixing Pins and Excision" Surgical Procedure for the "Rectum Prolapsus".

Frederick Salmon was born in Bath. From his early career, he was fond of surgery, mostly interested in proctology. He had been specialized in London at St Bartholomew's Hospital. He was the founder of "The Infirmary for the Relief of the Poor Afflicted with Fistula and Other Disease of the Rectum," and the writer of one of the most important surgical treatises, the " Practical Observations on Prolapsus of the Rectum." In this book, Salmon described an innovative operation for procidentia, based on the principle "trans-fixing pins and excision." Although his work was too significant for the era, he was almost completely neglected by historians, most probably due to his clash with his fellow surgeons, who had been considered by him as scientifically inadequate in anorectal diseases.

William Arbuthnot Lane (1856-1943): Surgical Innovator and His Theory of Autointoxication.

William Arbuthnot Lane contributed to the advancement of many fields of orthopedics, otolaryngology, and general surgery. He is credited for his "no-touch technique" and the invention of long-handled instruments, some of which are still in use today, to minimize tissue handling. He is most well known for his hypothesis that slowing of gastric contents could cause a variety of ailments and this became known as Lane's disease. Although his surgical treatment of Lane's disease is now defunct, it advanced the surgical technique in colorectal surgery. It seems likely that some of Lane's "autointoxication" patients would be classified today as patients with colonic inertia, diverticulitis, colonic volvulus, and megacolon or, which are all treated with colectomy. Lane was a pioneer in multiple fields and a true general surgeon. He advanced colorectal surgery immensely and propelled the field of surgery into a new era.